Data from the CHS data set were used to form a historical cohort of all 447 452 births delivered to mothers residing in NI during a 15-year period (between 1971 and 1986).29,30 Details were collated on the child (including gestational age, birth weight, and delivery method) from obstetric records at the time of delivery and on the mother (including mother’s age, parity, and area of residence) and the father (including father’s age and degree of consanguinity to the mother) by health visitors in the home, typically within 1 to 2 weeks of the birth.30 Health visitors are public health practitioners that provide support to all families in NI as part of the free-at-the-point-of-service National Health Service.31 After the introduction of the unique individual Health and Care Number (HCN) in 1998 (which replaced the previously used Community Health Index [CHI] identifier), the CHS data set was updated, allowing for direct one-to-one linkage to other contemporary health care–related data sets. Rudan
Unmasking is less common in highly heterozygous populations, so according to Bittles and Black, as cousin marriage declines, there should be corresponding increases in human health at a population level. JD, Stevenson et al. In addition, children of first-cousin consanguineous parents were more than twice as likely to be in receipt of antipsychotic medication compared with children of nonrelated parents. Across the world, approximately 1 in 10 children are the progeny of consanguineous parents despite concerns about the genetic safety of such a partnership.1 Consanguinity is defined as the union between 2 individuals related as second cousins or closer. N, Teimori Bener Another 1.3% were married to other relations and the …
Published Online: April 4, 2018. doi:10.1001/jamapsychiatry.2018.0133. D, Black However, psychopathology is known to be associated with mortality risk, meaning there is mortality bias in our results.
et al. Marital union among close biological kin is not uncommon. TM. All Rights Reserved. AH, Black Genetic counseling and screening of consanguineous couples and their offspring: recommendations of the National Society of Genetic Counselors.
Mental health of extremely low birth weight survivors in their 30s. In this population-wide cohort study of 363 960 participants, being a child of consanguineous parents was associated with having an increased likelihood of psychotropic medication use in adulthood. AH, Mahfoud Consanguineous marriages have been practiced since the early existence of modern humans. This factor likely excludes those with the most severe mental disorders, biasing the results toward the null, but does not affect the robustness of the observed associations.
Individuals with incomplete data in these fields may not have been successfully assigned an HCN. W, Dowling
K, Schmidt There is increasing evidence that highly consanguineous populations are more susceptible to certain infectious diseases like tuberculosis and hepatitis B. Blood relatives share same gene pool and act as carriers for genetic disorders, so inbreeding between close relatives highly favours transmission and expression of lethal genes in progeny leading to severe deleterious outcomes.
A child of first-cousin consanguineous parents is at increased risk of common mood disorders and psychoses.
However, the study design allowed for a robust examination of the mental health risk associated with consanguineous parents: the data were population wide, capturing an entire cohort born over 15 years, and contained detailed neonatal information on the individual and detailed sociodemographic information on the parents. N, Tantam
MA, Black A, Abou-Saleh S. Are neighbourhood characteristics associated with depressive symptoms?
a national survey of activities and service organisation. C, Kranz
R. Consanguineous marriages and their effects on pregnancy outcomes in India.
Child sex was identified from the CHS data set. There are several theories as to why consanguinity may result in mental ill health in progeny. Z, The highest rates of consanguineous marriages occur in south and west Asia, Middle East, and north Africa. sign up for alerts, and more, to access your subscriptions, sign up for alerts, and more, to download free article PDFs, sign up for alerts, customize your interests, and more, to make a comment, download free article PDFs, sign up for alerts and more, Archives of Neurology & Psychiatry (1919-1959), http://www.independent.co.uk/news/uk/home-news/london-borough-child-deaths-redbridge-parents-related-cousins-pakistani-families-council-report-a7741146.html, http://www.who.int/pmnch/media/news/2012/201204_borntoosoon-report.pdf, https://www.nisra.gov.uk/sites/nisra.gov.uk/files/publications/2001-census-results-key-statistics-report-tables.pdf, https://www.nisra.gov.uk/statistics/deprivation/northern-ireland-multiple-deprivation-measure-2010-nimdm2010, Schizophrenia Spectrum and Other Psychotic Disorders, FDA Approval and Regulation of Pharmaceuticals, 1983-2018, Global Burden of Skin Diseases, 1990-2017, Health Care Spending in the US and Other High-Income Countries, Life Expectancy and Mortality Rates in the United States, 1959-2017, Medical Marketing in the United States, 1997-2016, Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter, US Burden of Cardiovascular Disease, 1990-2016, US Burden of Neurological Disease, 1990-2017, Waste in the US Health Care System: Estimated Costs and Potential for Savings, Register for email alerts with links to free full-text articles.
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